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KMID : 0358819860130030287
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1986 Volume.13 No. 3 p.287 ~ p.295
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EXPERIMENTAL STUDY ON NERVE REGENERATION USING VEIN CONDUIT AND NERVE GRAFT -LIGHT AND ELECTRON MICROSCOPIC OBSERVATION
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Kim Suk-Wha
Kim Chin-Hwan
Seo Jeong-Wook
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Abstract
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The purpose of this article is to observe the effect of the inserted nervous tissue as a nerve graft on the nerve regeneration and downward growth into the distal portion of the severed nerve, even if, by the indirect method of comparing the autologous nerve graft with the autologous vein conduit.
We have compared the degree of regeneration in a transected sciatic nerve defeat through the autologous nerve graft with that through the vein conduit. Nerve defect was made by resection of 12 mm long segment in right and left sciatic nerves of 12 Sprague-Dawley rats respectively. The defect of left sciatic nerve was repaired with the nerve graft using contralateral sciatic nerve segment. The defect of right sciatic nerve was repaired with autologous vein conduit left jugular vein segment.
The repaired(grafted) segments of the right and left sciatic nerves and the distal portions were studied by the light and electron microscopy at 1,2,3, and 8 minths after graft.
Both in the nerve-grafted segments and in the vein-conduited segments, massive fibrosis was observed at 1 month. In the nerve-grafted segments, that fibrosis was resolved significantly by the infiltration of the regenerating axons at 3 months. But dense fibrosis still remained in the vein-conduited segments. Both the nerve-grafted segments and the vein-conduited segments showed almost complete regeneration at 8 months in the light microscopic study. But in the electron microscopic study, fascicular grouping of nerve fibers by fibrosis and schwann cell processes was observed only in the vein-conduited segments.
The above experimental results suggest indirectly that inserted autologous nerve graft effect more positively on the nerve regeneration and downward growth to the distal nerve portion than the vein conduit. More schematic and direct research will be necessary to confirm the exact mechanism of the trophic effect of the inserted nerve graft.
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KEYWORD
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